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Ask HN: What trick of the trade took you too long to learn?
118 points
by unsupp0rted
11h ago
192 comments
Tell HN: Anthropic expires paid credits after a year
59 points
by maytc
3h ago
28 comments
Ask HN: Why is it called "Vibe Coding"?
11 points
by giantg2
3h ago
9 comments
Ask HN: What change enabled you to consistently finish your side projects?
40 points
by pillefitz
13h ago
24 comments
People can exploit your social media pictures and so I've made a tool
4 points
by Gravyt1
6h ago
1 comments
Companies Tried to Save Money with AI Now Spending a Fortune to Fix Its Mistakes
5 points
by laurex
4h ago
1 comments
Ask HN: Who wants to be hired? (August 2025)
112 points
by whoishiring
3d ago
306 comments
Ask HN: What if I fail to make it?
6 points
by nextweeks
8h ago
13 comments
Ask HN: Who is hiring? (August 2025)
227 points
by whoishiring
3d ago
323 comments
Ask HN: What service should I use to send email from my Node.js application?
4 points
by TimCTRL
9h ago
6 comments
I launched 17 side projects. Result? I'm rich in expired domains
364 points
by cesargstn
5d ago
255 comments
Bitlocker Question
2 points
by donnylinux
9h ago
2 comments
Ask HN: Why does YC care what tech stack I use?
3 points
by codecracker3001
10h ago
2 comments
Ask HN: What are your best practices for Claude Code?
32 points
by hubraumhugo
1d ago
1 comments
Ask HN: How to Extract Shell Commands from Raw PTY Sessions? (Rewindtty)
2 points
by debba
15h ago
1 comments
I underestimated how lonely building solo can be
16 points
by paulwilsonn
2d ago
13 comments
Ask HN: Whats Your Observability Setup?
7 points
by okapi_creator
22h ago
1 comments
Claude Research refuses to answer questions about cytotoxic mushrooms
7 points
by posix_compliant
1d ago
5 comments
Ask HN: Want to leave my job with nothing lined up
38 points
by bsjak
2d ago
36 comments
Ask HN: Have you ever regretted open-sourcing something?
9 points
by paulwilsonn
2d ago
11 comments
AI Teammates for for Revenue Teams
3 points
by davismartens
2d ago
0 comments
Nova: A New Web Framework for Erlang
67 points
by taure
4d ago
27 comments
Ask HN: Is fast.ai's "Deep Learning for Coders" still relevant in 2025?
12 points
by hedgehog0
2d ago
3 comments
Ask HN: Why was Windows ME so bad?
10 points
by alganet
1d ago
12 comments
Claude Code weekly rate limits
607 points
by thebestmoshe
7d ago
703 comments
Ask HN: What are you working on? (July 2025)
260 points
by david927
8d ago
857 comments
Ask HN: Will AI push more of us into freelancing?
15 points
by gashmol
2d ago
16 comments
Ask HN: Who'd join a San Diego HN meetup?
4 points
by cjbarber
1d ago
1 comments
Ask HN: How do you avoid job hunting burnout?
19 points
by b8
3d ago
12 comments
Ask HN: How is it possible to get -0.0 in a sum?
10 points
by gus_massa
2d ago
7 comments
Cardano Community Approves $71M Treasury Plan to Boost Network Upgrades
2 points
by AbdulHype
19h ago
0 comments
Ask HN: Is true democracy possible in online tech communities?
13 points
by ff12wq111
3d ago
43 comments
Ask HN: What crypto payments options should I offer for my VPN?
5 points
by willprice89
2d ago
9 comments
Kyoto University team develops pain reliever comparable to morphine
20
nogajun
2
8/5/2025, 3:47:18 AM
japantimes.co.jp ↗
Comments (2)
burnt-resistor
· 22m ago
A new class of selective α2B-adrenoceptor antagonist.
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petesergeant
· 27m ago
Marginally more info, along with the title of the paper, but the doi is broken:
https://medicalxpress.com/news/2025-08-discovery-analgesic-p...
There's also the alternative Journavx:
https://en.wikipedia.org/wiki/Suzetrigine
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There's also the alternative Journavx: https://en.wikipedia.org/wiki/Suzetrigine