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Curl Turns 10k Days (github.com)

1 points by robin_reala 2m ago 0 comments

Adaptive Political Economy: Toward a New Paradigm (muse.jhu.edu)

1 points by hunglee2 2m ago 0 comments

Where to find ideas – by Rob Snyder (howtogrow.substack.com)

1 points by kiyanwang 3m ago 0 comments

Apache ECharts 6 New Features (echarts.apache.org)

1 points by makepanic 8m ago 0 comments

Show HN: I built Deep Research for SEO keywords (jelloseo.com)

1 points by grantsingleton 8m ago 0 comments

Show HN: FlexLLama – Run multiple local LLMs at once with a simple dashboard (github.com)

2 points by yazon 10m ago 0 comments

Real-time neural video codec – 100 FPS 1080p and 4K videos (github.com)

1 points by selvan 10m ago 0 comments

In Support of Shitty Types (lucumr.pocoo.org)

1 points by ingve 19m ago 0 comments

How the Brain Protects Itself from Blood-Borne Threats (quantamagazine.org)

1 points by signa11 21m ago 0 comments

ChatGPT Agent's User-Agent (simonwillison.net)

1 points by ingve 26m ago 0 comments

Imaging reveals 2k-year-old ice mummy's 'incredibly impressive' tattoos (cbc.ca)

2 points by empressplay 30m ago 0 comments

China pushes back at US demands to stop buying Russian and Iranian oil (apnews.com)

1 points by mhga 34m ago 0 comments

World in $1.5T 'plastics crisis' hitting health from infancy to old age (theguardian.com)

1 points by benkan 34m ago 0 comments

India Will Buy Russian Oil Despite Trump's Threats, Officials Say (nytimes.com)

1 points by mhga 35m ago 0 comments

Google agrees to pause AI workloads when power demand spikes (theregister.com)

1 points by benkan 35m ago 0 comments

Duffy to announce nuclear reactor on the moon (politico.com)

1 points by benkan 37m ago 0 comments

AI Rewrote Its Code When I Asked About Human Nature (psychologytoday.com)

1 points by aard 44m ago 0 comments

Show HN: LinkJolt – SaaS affiliate tracking with 0% fees (linkjolt.io)

1 points by frostydog111 47m ago 0 comments

Ask HN: What are some resources to learn about building infra for AI workloads?

1 points by lambdafunct 51m ago 0 comments

Show HN: I created an AI-powered Python testing suite that writes its own tests

1 points by MarcoDewey 54m ago 0 comments

Show HN: Code Index MCP – Codebase Indexing Server for LLMs (github.com)

2 points by johnhuang316 57m ago 0 comments

Before AWS existed, one company ran the servers for Twitter, LinkedIn, Facebook (threadreaderapp.com)

3 points by taubek 1h ago 0 comments

Strengthening F-Droid's Legal Resilience – Introducing the Research Series (f-droid.org)

1 points by mgd 1h ago 0 comments

Welcome to the IPv4 Games (ipv4.games)

3 points by chillax 1h ago 0 comments

Ask HN: Parenting with Minecraft Coins?

1 points by p1anecrazy 1h ago 1 comments

Slopwatch: Fake Linux 'Articles' and Slopfarms with "Linux" in Their Names (techrights.org)

1 points by jruohonen 1h ago 1 comments

Cheqbooq: Your Bank Transactions, Translated Into Insights (cheqbooq.com)

1 points by soomrozaid 1h ago 1 comments

ChatGPT adds mental health guardrails after fell short in recognizing delusion (nbcnews.com)

3 points by nradov 1h ago 0 comments

Monitor your security cameras with locally processed AI (frigate.video)

73 points by zakki 1h ago 16 comments

Microsoft's Failed Strategy – Security as an Afterthought (securityboulevard.com)

3 points by WaitWaitWha 1h ago 0 comments

Show HN: A simple website to analyze mortgage called "Mortlab" (mortlab.com)

2 points by branga 1h ago 0 comments

Polish Train Maker Is Suing the Hackers Who Exposed Its Anti-Repair Tricks (de.ifixit.com)

6 points by xrayarx 1h ago 0 comments

Troubling scenes from an Arctic in full-tilt crisis (grist.org)

2 points by minhduong243 1h ago 0 comments

AI Playbook for the Great Game (romeviharo.substack.com)

1 points by hoofish 1h ago 1 comments

takeaways from 28 factory tours in 14 days (twitter.com)

2 points by zachglabman 1h ago 0 comments

Oceans Seven (en.wikipedia.org)

1 points by xrayarx 1h ago 0 comments

CEOs Are Publicly Boasting About Reducing Their Workforces with AI (futurism.com)

3 points by aard 2h ago 0 comments

Columbia Scientists Made a Gel from Yogurt That Heals Tissue, and It Works (scitechdaily.com)

3 points by aard 2h ago 0 comments

Thoughts on Henry Ford and the UX (jonkolko.com)

1 points by AbbeFaria 2h ago 0 comments

When AI Gets Its Hands (rashidazarang.com)

2 points by rashidae 2h ago 1 comments

Raspberry Pi Expands Embedded Lineup with Low-Cost Radio and Camera Modules (linuxgizmos.com)

4 points by teleforce 2h ago 0 comments

Strategic Incompetence: How to Create Capacity and Earn Your Next Title (swecareer.substack.com)

2 points by thathoo 2h ago 0 comments

One Way Parents Can Fight the Phone-Based Childhood (theatlantic.com)

2 points by pabo 2h ago 0 comments

New terminal-based LLM coding tool (github.com)

1 points by nairbv 2h ago 1 comments

ChatGPT and the Meaning of Life (scottaaronson.blog)

2 points by algorithmista 2h ago 0 comments

Google is making it easier to hide sensitive files in your Pixel's Private Space (androidauthority.com)

1 points by colinprince 2h ago 0 comments

Try Qwen Image Online (qwen-image.ai)

1 points by blacktechnology 2h ago 0 comments

California could slash 5 GOP House seats to counter Texas (apnews.com)

4 points by mark336 2h ago 0 comments

Getting Started with Randomised Testing (lewiscampbell.tech)

2 points by xupybd 2h ago 0 comments

PHP 8.5 adds pipe operator (thephp.foundation)

76 points by lemper 2h ago 30 comments

Kyoto University team develops pain reliever comparable to morphine

39 nogajun 6 8/5/2025, 3:47:18 AM japantimes.co.jp ↗

Comments (6)

burnt-resistor · 1h ago
A new class of selective α2B-adrenoceptor antagonist.
erickhill · 38m ago
Why is this written in such a way to only target cancer patients?
bitwize · 36m ago
The class of patients most likely to require opioids over long periods of time?
delusional · 33m ago
And a class disproportionately insensitive to long term negative side effects.
kelseyfrog · 49m ago
How is it different from Imiloxan?
petesergeant · 1h ago
Marginally more info, along with the title of the paper, but the doi is broken: https://medicalxpress.com/news/2025-08-discovery-analgesic-p...

There's also the alternative Journavx: https://en.wikipedia.org/wiki/Suzetrigine