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RFK Jr. to require placebo-controlled studies for new vaccines
37 srameshc 29 5/1/2025, 11:25:29 PM npr.org ↗
Is the hypothesis that there is some kind of psychosomatic/placebo effect to vaccines, where just the process of getting injected changes outcomes? I find that hard to believe.
The reason the updates aren't currently tested this way is because medical research ethics perspectives on the balance of risk of novel unknown effects vs known risk of withholding effective treatment from the placebo group. https://en.wikipedia.org/wiki/Clinical_equipoise
Randomly expose patients to the risk of contracting a known debilitating/deadly disease
Or
No one who comes in for the vaccine will consent the trial
In tech terms they're the principal architects now and they're using that power to get their preferences on minor PR reviews merged.
Nothing about this moment created conditions for such a thing.
There was no support for such a thing and no real promiss to do such a thing. No track record fod GOP proposing good regulation.
Project 2025 was known and not about helping people. The anto vaccine regulations are already a thing in red states.
https://www.bmj.com/content/363/bmj.k5094
Without that we delay treatment, increase costs, and slow research. And people die while we wait.
Test what's most likely to be a problem, and avoid wasting resources proving what we already know.
This is for new vaccines: we're not halting administration of existing vaccines. And the time taken for testing new vaccines seems reasonable for safety purposes, as it would be for any other medicine.
If annual influenza vaccines cannot be approved in time for flu season and flu deaths increase significantly over the years to come, would you consider that justifiable?
The article mentions ‘ four years ago is unacceptable so it sounds like they want to retest new versions every four years, rather than every new version.
Your choice of quote makes it seem like you are misunderstanding or deliberately misrepresenting the article. In more context:
> "As we've said before, trials from four years ago conducted in people without natural immunity no longer suffice. A four-year-old trial is also not a blank check for new vaccines each year without clinical trial data, unlike the flu shot which has been tried and tested for more than 80 years," Nixon said in a statement he had earlier sent to The Washington Post. "The public deserves transparency and gold-standard science — especially with evolving products."
This states that a Covid vaccine passing the placebo-controlled study requirement 4 years ago will not suffice to accept updated versions of the same Covid vaccine -- not that vaccines and/or delivery mechanisms will only need to be tested every 4 years. More concisely: it's an upper bound, but not a lower bound.
Edit: Fixing up some grammar.
Yes. That is what the comment you were replying to states.
> More concisely: it's an upper bound, but not a lower bound.
You can’t say it’s any bound at all. Maybe more than two milliseconds old (less than four years) is unacceptable, maybe 16 millennia (more than four years) is unacceptable. They’re just thinking about four years as being unacceptable. Which sounds reasonable.
> An ethical dilemma arises in a clinical trial when the investigator(s) begin to believe that the treatment or intervention administered in one arm of the trial is significantly outperforming the other arms. A trial should begin with a null hypothesis, and there should exist no decisive evidence that the intervention or drug being tested will be superior to existing treatments, or that it will be completely ineffective. As the trial progresses, the findings may provide sufficient evidence to convince the investigator of the intervention or drug's efficacy. Once a certain threshold of evidence is passed, there is no longer genuine uncertainty about the most beneficial treatment, so there is an ethical imperative for the investigator to provide the superior intervention to all participants.
> https://en.wikipedia.org/wiki/Clinical_equipoise
In any event, no one suggested a reduction in testing.
> "except for the COVID vaccine, none of the vaccines on the CDC's childhood recommended schedule was tested against an inert placebo, meaning we know very little about the actual risk profiles of these products."
Given the answer is clearly and obviously “none”, why do you think you’re qualified to have any opinion at all?
In case you are new to adult discourse, many people, including yourself have opinions on matters that they are not experts in.
Despite the question above, you are in fact allowed to have opinions on whether there should be more or less testing of medicine.
The same way you have opinions about geopolitics despite the fact that you don’t sit on private committees or serve in the military.
You can have opinions about tech products without having written their source code or even writing any of your own.