They gave the mice 15mg, which is about a low-medium dose for a human. But humans weigh about 2000 times what mice do, so the effects were observed at about 2k times a reasonable dose.
1) Those mice must have been completely out of it.
2) This probably isn’t helpful to humans unless given under sedation. Or maybe that extreme a dose is equivalent to sedation, I’m not sure anyone has taken 30 _grams_ of psilocybin to tell us?
pjerem · 1h ago
I’m not an expert so I’ll just ask questions but IIRC, there is no deadly dose of psylocybin.
I would imagine that at some point the effects would plateau. Of course you would be pretty far away in space in multiple dimensions at the same time.
I would be surprised, if this plateau exists, that nobody would have reached it.
In psychedelics space, it’s not unheard of people accidentally taking 100-1000x the expected dose and having the best (or worse) time of their life without further health issues.
Also it seems that set&setting is far more important for the experience than the actual dose.
coffeebeqn · 10m ago
You’d probably do profound psychological damage to yourself. It’s not deadly but that doesn’t mean it won’t affect you permanently to be stuck in some kind of a hell for what will feel like an eternity
funnym0nk3y · 1h ago
In general mice need larger doses of most medication candidates. AFAIK this is because they have a faster metabolism compared to humans.
In addition I don't think there is a overdose risk with psychedelics.
contrarian1234 · 1h ago
I have no personal experience with mushrooms, but I never understood why placebo trials aren't done while the patients are asleep.
Just choose research subjects that don't remember their dreams and who sleep a solid 8 hours
I think a trip is much shorter than 8 hours and by the time you wake up you wouldn't be able to tell the difference
bubblyworld · 1h ago
It's very difficult to sleep under the influence of a moderate psilocybin dose. Or any other of the classic psychedelics for that matter, like LSD or mescaline.
I'm not sure what the mechanism is but they definitely have a stimulant-like feel sometimes (especially LSD).
ddalex · 51m ago
So you have it right, just need to take it in the morning before going to work
canogat · 36m ago
I grew some mushrooms at home for the first time. Ate one at 8pm at a concert tonight. Its now 3am and despite taking melatonin, I cannot get to sleep.
coffeebeqn · 4m ago
That’s normal. Best to just relax maybe have some food/drink and eventually you’ll sleep but it’s not a party drug if you’re gonna work the next day or something
cyann · 26m ago
Melatonin is effective ~5 hours later. No need to take more than 0.3 mg.
What you should try is L-Theanine just before going to sleep, it's effective against Caffeine, not sure about Psilocybin.
JoeyJoJoJr · 1h ago
I don’t really remember my dreams anymore, but if I go to bed having consumed weed (or one time, a light dose of mushrooms) I end up having a psychedelic version of fever dreams - extremely intense visualisations of thought structures that just keep folding out of themselves, that appear otherwise unfathomly huge and intricate. It’s quite uncomfortable wanting to sleep and rest from your thoughts but the substance won’t let you.
pas · 1h ago
30 grams of pure psilocybin? that requires eating 3 kilograms of mushrooms, right? usually it's 1% (or less) of dried mass.
well, actually more "doable" than initially I have assumed, but it would quickly lead to vomiting and a pretty guaranteed bad trip, well before ingesting enough.
also interestingly LD50 is
280 mg/kg.
tinco · 1h ago
Wouldn't this much psycobylin severely affect your personality?
esseph · 4h ago
I'm not actually interested in anti-aging, but this is still interesting!
yieldcrv · 3h ago
Just got to get it approved for anything and …. well everything will be the same. I’ve seen so many vendors selling professionally packed psilocybin. I’m like “this is like Lion’s Mane..?” Nope, just drugs!
But at least you can talk about it with your family and coworkers more casually
This is exactly what the world needs, a bunch of tripping boomers showing us just how wrecked the pension systems are!
surfingdino · 1h ago
What "assisted dying" legislation is being introduced for. Start with "humane approach to suffering" end up with "right, you have no savings, and you have been taking your pension for way too long, we suggest a humane termination, here's your goodbye pill"
throw__away7391 · 12m ago
Well at the moment around the world the young are being sacrificed to provide comfort for the old. The older generations have set up unsustainable pensions and welfare programs for themselves, all sorts of protections for their seniority, carve outs and exemptions for paying their fair share of the ever increasing costs of these measures, and ballooned debts at every level of governments that they themselves will never have to pay back, with most of the spending on themselves. This is happening in nearly every country in the world.
beardyw · 2h ago
We need drugs to help people understand they are mortal.
globular-toast · 56m ago
I used to think I was "awake" because I became intensely aware of my mortality in my early 20s. But actually I feel like that's the norm, these days.
Gen Z seem to take "YOLO" seriously from a young age. Nobody is planning for anything beyond their own lifetimes. Some people still can't resist their biological imperative and have kids, but they're all basically YOLOing their lifestyles and their actions, if not their words, are saying "not my problem, you'll figure it out when I'm gone".
So, yeah, be aware you won't be here forever, but what we need is for people to leave the damn place in a better state than they found it, or at least not worse.
1) Those mice must have been completely out of it. 2) This probably isn’t helpful to humans unless given under sedation. Or maybe that extreme a dose is equivalent to sedation, I’m not sure anyone has taken 30 _grams_ of psilocybin to tell us?
I would imagine that at some point the effects would plateau. Of course you would be pretty far away in space in multiple dimensions at the same time.
I would be surprised, if this plateau exists, that nobody would have reached it.
In psychedelics space, it’s not unheard of people accidentally taking 100-1000x the expected dose and having the best (or worse) time of their life without further health issues.
Also it seems that set&setting is far more important for the experience than the actual dose.
Just choose research subjects that don't remember their dreams and who sleep a solid 8 hours
I think a trip is much shorter than 8 hours and by the time you wake up you wouldn't be able to tell the difference
I'm not sure what the mechanism is but they definitely have a stimulant-like feel sometimes (especially LSD).
What you should try is L-Theanine just before going to sleep, it's effective against Caffeine, not sure about Psilocybin.
well, actually more "doable" than initially I have assumed, but it would quickly lead to vomiting and a pretty guaranteed bad trip, well before ingesting enough.
also interestingly LD50 is 280 mg/kg.
But at least you can talk about it with your family and coworkers more casually
Psilocybin treatment extends cellular lifespan, improves survival of aged mice (nature.com)
43 points | 1 day ago | 10 comments https://news.ycombinator.com/item?id=44527358
Psilocybin for major depression granted Breakthrough Therapy by FDA (newatlas.com)
1240 points | 6 years ago | 471 comments https://news.ycombinator.com/item?id=21638290
What happens when clergy take psilocybin (nautil.us)
353 points | 25 days ago | 566 comments https://news.ycombinator.com/item?id=44293610
Gen Z seem to take "YOLO" seriously from a young age. Nobody is planning for anything beyond their own lifetimes. Some people still can't resist their biological imperative and have kids, but they're all basically YOLOing their lifestyles and their actions, if not their words, are saying "not my problem, you'll figure it out when I'm gone".
So, yeah, be aware you won't be here forever, but what we need is for people to leave the damn place in a better state than they found it, or at least not worse.