Show HN: RULER – Easily apply RL to any agent (openpipe.ai)
69 points by kcorbitt 1d ago 11 comments
Show HN: Cactus – Ollama for Smartphones (github.com)
217 points by HenryNdubuaku 1d ago 81 comments
Psilocybin shows promise as anti-aging therapy
86 joak 40 7/12/2025, 5:01:19 AM neurosciencenews.com ↗
1) Those mice must have been completely out of it. 2) This probably isn’t helpful to humans unless given under sedation. Or maybe that extreme a dose is equivalent to sedation, I’m not sure anyone has taken 30 _grams_ of psilocybin to tell us?
I would imagine that at some point the effects would plateau. Of course you would be pretty far away in space in multiple dimensions at the same time.
I would be surprised, if this plateau exists, that nobody would have reached it.
In psychedelics space, it’s not unheard of people accidentally taking 100-1000x the expected dose and having the best (or worse) time of their life without further health issues.
Also it seems that set&setting is far more important for the experience than the actual dose.
The question remains though: would it still have the same effects? The psychological effects are certainly diminished with tolerance, but who knows if this study's findings act on the same/a similar mechanism.
And this is not a one-off thing, but a monthly regimen. So we're talking about taking a dose that's way beyond heroic, every month, for the rest of your life. That's so far outside the realm of responsible psychedelic use, I don't think any human has even come close to attempting it. The only thing that's for certain is there's no way of knowing what the psychological effects would be, but I have a hard time believing it wouldn't get extremely ugly.
Just choose research subjects that don't remember their dreams and who sleep a solid 8 hours
I think a trip is much shorter than 8 hours and by the time you wake up you wouldn't be able to tell the difference
I'm not sure what the mechanism is but they definitely have a stimulant-like feel sometimes (especially LSD).
What you should try is L-Theanine just before going to sleep, it's effective against Caffeine, not sure about Psilocybin.
Mass is proportional to volume. Volume increases super-linearly with respect to area. Therefore area increases sub-linearly compared to volume. Therefore dose increases sub-linearly with respect to volume. Therefore does increases sub-linearly with respect to mass.
well, actually more "doable" than initially I have assumed, but it would quickly lead to vomiting and a pretty guaranteed bad trip, well before ingesting enough.
also interestingly LD50 is 280 mg/kg.
As long as one of them can code I’ll be fine
Bonus if the other one can do marketing
But at least you can talk about it with your family and coworkers more casually
If not, I would want better mushrooms than that myself :)
Let me know when this is completely well-proven, I have a friend who's an older gentleman . . .
Psilocybin treatment extends cellular lifespan, improves survival of aged mice (nature.com)
43 points | 1 day ago | 10 comments https://news.ycombinator.com/item?id=44527358
Psilocybin for major depression granted Breakthrough Therapy by FDA (newatlas.com)
1240 points | 6 years ago | 471 comments https://news.ycombinator.com/item?id=21638290
What happens when clergy take psilocybin (nautil.us)
353 points | 25 days ago | 566 comments https://news.ycombinator.com/item?id=44293610
Gen Z seem to take "YOLO" seriously from a young age. Nobody is planning for anything beyond their own lifetimes. Some people still can't resist their biological imperative and have kids, but they're all basically YOLOing their lifestyles and their actions, if not their words, are saying "not my problem, you'll figure it out when I'm gone".
So, yeah, be aware you won't be here forever, but what we need is for people to leave the damn place in a better state than they found it, or at least not worse.
Can you blame them? Boomers are saying the exact same thing while treating CO2 emissions like they're the main ingredient of a goddamned Werther's Original. Living here is only going to get harder as Gen Z gets older. "Fuck it, enjoy it while it's good" is a rational sentiment when you're born into an ongoing catastrophe that is actively being made worse.
Climate change, automation threatening the value of human labor, rise of authoritarianism, "the West" losing it's hegemonic status, wars, genocides.
Hard to make long term plans for your life when the world is changing rapidly and we don't even know how it will look like in 10 years.