"A large new study published in the International Journal of Hygiene and Environmental Health provides evidence that exposure to certain workplace chemicals among parents may influence the severity of autism spectrum disorder (ASD) symptoms and contribute to behavioral, cognitive, and adaptive challenges in their children. The findings suggest that occupational exposures—especially to plastics, ethylene oxide, phenols, and pharmaceutical agents—may have broader developmental effects beyond autism diagnosis alone."
"The findings suggest that workplace exposures to several specific chemical classes were associated with worse outcomes in children with ASD. One of the strongest and most consistent patterns involved plastics and polymer chemicals. Fathers’ exposure to plastics was associated with lower scores across all cognitive and adaptive skill domains, including language, motor coordination, daily living skills, and overall functioning. When both parents were exposed, the deficits appeared to compound.
“I was surprised how strongly and consistently plastics and polymers stood out as being linked with multiple developmental and behavioral outcomes including irritability, hyperactivity, and daily living,” McCanlies told PsyPost.
Exposure to ethylene oxide—commonly used in hospital sterilization—was also linked to more severe autism symptoms, lower expressive language abilities, and poorer adaptive functioning. Similarly, parental exposure to phenol (used in construction, automotive, and some consumer products) and pharmaceuticals was associated with increased ASD severity and more pronounced behavioral challenges, especially hyperactivity and stereotyped behavior.
While the results do not imply that all children exposed to these chemicals will develop more severe symptoms, the patterns suggest that early life exposure to workplace toxicants may amplify certain developmental difficulties in children who already meet criteria for ASD. The study provides one of the most detailed looks to date at how parental occupation may relate not just to diagnosis, but to variation in how autism is expressed.
“Our findings suggest that certain parental workplace exposures may be related not just to autism, but to worse symptoms and autism behaviors,” McCanlies explained."
vnchr · 19m ago
It’s settled science
austin-cheney · 2h ago
Some forms of autism are highly inheritable. Asperger's Syndrome is inheritable at a rate of about 80%. In these cases the cause is genetic, but genetics is likely only one of many potential causes.
'
zug_zug · 1h ago
But even "genetics" isn't really a single cause because it's over 200 different genes that each have an effect.
nis0s · 3h ago
It occurs to me that pain killers can cross the placenta and also affect gut microbes, and that since sometimes autism isn’t inherited, there’s a gut microbe imbalance component to autism that needs more attention, especially related to how gut microbes differ in those born with and without Caesarians. Secondly, how are genes related to autism also linked to the gut-brain axis.
Gut health isn’t mentioned in the article, so it seems like a good point to bring up.
kristianp · 35m ago
> also affect gut microbes
Which painkillers? Do you have a citation for that? Note that ibuprofen is generally prohibited in pregnancy.
mikestew · 2h ago
You’re not saying Tylenol causes autism, are you?
nis0s · 2h ago
I am saying it’s possible there’s a gut-brain axis being affected by any number of factors. Consider Caesarian babies. I didn’t look it up, but I think since Caesarian babies aren’t exposed to bacteria from the vaginal canal, it perhaps contributes to their condition.
RAM-bunctious · 2h ago
It's technically possible that early-life microbiome differences from bypassing the birth canal could influence it, but the fact that the association disappears when siblings who were delivered differently are compared is suggestive.
> Other factors that have been linked to autism include people being born prematurely or through cesarean section, as well as pregnant people having obesity, using certain medications (such as the antiseizure drug valproate) and the pain reliever acetaminophen (the active ingredient in Tylenol) and being exposed to air pollution. The strength of the evidence for these links varies, though, and the increases in risk tend to be small. The evidence is also only correlational, meaning it can’t establish what caused what.
> Acetaminophen is also usually used as a fever reducer, which pregnant people might take if they are fighting an infection. Both infections and uncontrolled fevers during pregnancy have been linked to higher rates of autism. “We know that the neurodevelopmental outcomes of having an uncontrolled fever are worse than what we’re observing for acetaminophen,” Mandell says.
"The effects of parental occupational exposures on autism spectrum disorder severity and skills in cognitive and adaptive domains in children with autism spectrum disorder" https://www.sciencedirect.com/science/article/pii/S143846392...
The person leading this study, Erin C. McCanlies, was forced out of the CDC, her division eliminated and she went into early retirement from the CDC. https://www.psypost.org/scientist-who-linked-autism-to-chemi...
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"The findings suggest that workplace exposures to several specific chemical classes were associated with worse outcomes in children with ASD. One of the strongest and most consistent patterns involved plastics and polymer chemicals. Fathers’ exposure to plastics was associated with lower scores across all cognitive and adaptive skill domains, including language, motor coordination, daily living skills, and overall functioning. When both parents were exposed, the deficits appeared to compound.
“I was surprised how strongly and consistently plastics and polymers stood out as being linked with multiple developmental and behavioral outcomes including irritability, hyperactivity, and daily living,” McCanlies told PsyPost.
Exposure to ethylene oxide—commonly used in hospital sterilization—was also linked to more severe autism symptoms, lower expressive language abilities, and poorer adaptive functioning. Similarly, parental exposure to phenol (used in construction, automotive, and some consumer products) and pharmaceuticals was associated with increased ASD severity and more pronounced behavioral challenges, especially hyperactivity and stereotyped behavior.
While the results do not imply that all children exposed to these chemicals will develop more severe symptoms, the patterns suggest that early life exposure to workplace toxicants may amplify certain developmental difficulties in children who already meet criteria for ASD. The study provides one of the most detailed looks to date at how parental occupation may relate not just to diagnosis, but to variation in how autism is expressed.
“Our findings suggest that certain parental workplace exposures may be related not just to autism, but to worse symptoms and autism behaviors,” McCanlies explained."
Gut health isn’t mentioned in the article, so it seems like a good point to bring up.
Which painkillers? Do you have a citation for that? Note that ibuprofen is generally prohibited in pregnancy.
"However, the association did not persist when using sibling controls, implying that this association is due to familial confounding by genetic and/or environmental factors." - https://jamanetwork.com/journals/jamapsychiatry/fullarticle/...
> Other factors that have been linked to autism include people being born prematurely or through cesarean section, as well as pregnant people having obesity, using certain medications (such as the antiseizure drug valproate) and the pain reliever acetaminophen (the active ingredient in Tylenol) and being exposed to air pollution. The strength of the evidence for these links varies, though, and the increases in risk tend to be small. The evidence is also only correlational, meaning it can’t establish what caused what.
> Acetaminophen is also usually used as a fever reducer, which pregnant people might take if they are fighting an infection. Both infections and uncontrolled fevers during pregnancy have been linked to higher rates of autism. “We know that the neurodevelopmental outcomes of having an uncontrolled fever are worse than what we’re observing for acetaminophen,” Mandell says.