Ask HN: What toolchains are people using for desktop app development in 2025?

90 points by lincoln20xx 20h ago 91 comments

What's your favorite CLI tool for integrating LLMs into your terminal workflow?

4 points by menisadi 3h ago 1 comments

Ask HN: How can ChatGPT serve 700M users when I can't run one GPT-4 locally?

518 points by superasn 1d ago 332 comments

GPT5 is worse than 4.1-mini for text and worse than Sonnet 4 for coding

5 points by hitradostava 3h ago 13 comments

ChatGPT 5 is slow and no better than 4

54 points by iwontberude 19h ago 37 comments

Ask HN: Canadian founders, how do you build in SF?

4 points by changisaac 7h ago 0 comments

Ask HN: What trick of the trade took you too long to learn?

374 points by unsupp0rted 5d ago 649 comments

Ask HN: Has any of the Pivotal Tracker replacement attempts succeeded?

46 points by admissionsguy 6d ago 34 comments

Tell HN: Anthropic expires paid credits after a year

270 points by maytc 5d ago 135 comments

Ask HN: In which programming language is it better to make your own language?

8 points by Forgret 22h ago 16 comments

Ask HN: OpenAI GPT-5 API seems to be significantly slower – is this expected?

4 points by tlogan 18h ago 3 comments

Ask HN: How do you find honest tech reviews?

7 points by bjourne 21h ago 6 comments

Ask HN: How would you build second brain in the AI era?

8 points by divan 1d ago 5 comments

Ask HN: What do you dislike about ChatGPT and what needs improving?

32 points by zyruh 3d ago 123 comments

Exposing Satcom in the Sky: Aircraft Systems Vulnerable to Remote Attacks

2 points by hacker_might 1d ago 0 comments

Countries with most GPT-5 users, esp. in advanced computation and reasoning?

2 points by mzk_pi 1d ago 2 comments

ChatGPT-5 Can't Do Basic Math

15 points by MarcellusDrum 1d ago 13 comments

Tell HN: Chrome and Spotify dropping support for macOS11

9 points by Kalanos 1d ago 7 comments

GPT-5 streaming requires submission of biometric data

32 points by binarymax 1d ago 7 comments

Ask HN: Are you running local LLMs? What are your key use cases?

12 points by briansun 1d ago 12 comments

Ask HN: Claude Code vs. Codex vs. GitHub Coding Agent?

2 points by endorphine 1d ago 1 comments

Tell HN: Charles Irby has passed away

31 points by steven123 2d ago 4 comments

Ask HN: Which processor to pick for learning assembly?

8 points by shivajikobardan 2d ago 7 comments

Ask HN: Should brain implants be available for everyone as a productivity boost?

2 points by amichail 1d ago 4 comments

Ask HN: Why Did Mercurial Die?:(

29 points by sergiotapia 4d ago 32 comments

Ask HN: Recommendations for specification management software?

7 points by gusmally 2d ago 1 comments

Ask HN: What are you working on this weekend?

10 points by lagniappe 1d ago 17 comments

White Paper: Contribution-Based Governance for Developer Communities

4 points by ff12wq111 1d ago 2 comments

Ask HN: What change enabled you to consistently finish your side projects?

49 points by pillefitz 5d ago 39 comments

Tell HN: Thing I learned this year was keeping a work journal

11 points by Muromec 2d ago 9 comments

Flycrypto – Book Flights and Hotels with Bitcoin and Crypto

3 points by flycrypto 2d ago 3 comments

Ask HN: Oreilly Courses Recommendations

2 points by ankitg12 4d ago 1 comments

Machine learning highlights factors associated with Arabidopsis circadian clock

2 bryanrasmussen 1 8/9/2025, 12:32:42 PM nature.com ↗

Comments (1)

bryanrasmussen · 1d ago

original title: Machine learning models highlight environmental and genetic factors associated with the Arabidopsis circadian clock