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Tobacco CEOs testify: "Nicotine is not addictive" (1994)
16 andrewstetsenko 5 6/9/2025, 8:57:41 PM pbs.org ↗
Perhaps the true value of executives that justifies their bloated compensation is the ability to deliver bullshit lines like these with a straight face.
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What is very addictive, though, is the synergistic effect nicotine has with MAO inhibitors, such as those found in tobacco smoke or vape/gum/pouch flavorings.
Reinforcement and MAO-A inhibition in heated tobacco products: flavor and brand variations https://www.frontiersin.org/journals/psychiatry/articles/10....
Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products https://www.sciencedirect.com/science/article/pii/S221475001...
There is of course variance depending on the exact flavorants used. For example, menthol and mint flavors don’t inhibit MAO, their activity is towards kappa-opioid agonism (induction of dysphoria).