Inflammation predicts 25% higher mortality

13 brandonb 4 8/24/2025, 11:01:44 PM thelancet.com ↗

Comments (4)

brandonb · 3h ago
This study followed 5,294 people for 20 years. People in the highest third of inflammation (hs-CRP > 5) had 32% higher chance of heart disease and 25% higher mortality from any cause.

Inflammation was a predictor even when you take cholesterol, blood pressure, BMI, etc into account. (The researchers trained various models to test this.)

Inflammation is pretty easy to measure in a blood test. Lots of places online: https://www.empirical.health/product/comprehensive-health-pa...

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duffpkg · 2h ago
This headline is heavily editorialized and does not correspond with the title or findings of the study linked.
brandonb · 2h ago
The paper's original title is 66 characters too long for HN.

The "25% higher mortality" comes from the all-cause mortality result in "Findings", which is one of the main results of the paper. The paper expresses it as a hazard ratio (HR) of 1.25 [1.10–1.42]. Hazard ratios are standard in medical research, but I wanted to summarize the main result without jargon.

hinkley · 2h ago
Luckily I can only be 100% dead.