Sounds like probiotics are the path to natural GLP-1 upregulation via metabolites of B. vulgatus? Is Western structural obesity potentially caused by broad spectrum antibiotic usage impairing certain gut flora?
0cf8612b2e1e · 12h ago
From the abstract, the supplement was B5. I would naively expect that if B5 suppressed appetite, someone would have previously noted this effect.
gamblor956 · 9h ago
I think you read the wrong article. The abstract states that gut bacteria is the key:
"ugar preference is a key contributor to the overconsumption of sugar and the concomitant increase in the incidence of diabetes. However, the exact mechanism of its development remains ambiguous. Here we show that the expression of free fatty acid receptor Ffar4, a receptor for long-chain fatty acids, is decreased in patients and mouse models with diabetes, which is associated with high sugar intake. Deletion of intestinal Ffar4 in mice resulted in reduced gut Bacteroides vulgatus and its metabolite pantothenate, leading to dietary sugar preference. Pantothenate promoted the secretion of GLP-1 which inhibited sugar preference by stimulating hepatic FGF21 release, which in turn regulates energy metabolism. These findings uncover a previously unappreciated role of Ffar4 in negatively regulating sugar preference and suggest B. vulgatus-derived pantothenate as a potential therapeutic target for diabetes."
0cf8612b2e1e · 7h ago
My reading from that blurb is that supplementing pantothenate (B5) leads to GLP-1 secretion and curbing of appetite. A proper gut flora already has B. vulgatus which secretes pantothenate, so no need to supplement.
toomuchtodo · 6h ago
Wouldn’t people without weight challenges be the ones with a proper gut flora? And those without be the ones needing a repopulation of B. vulgatus?
smackeyacky · 12h ago
Possibly antibiotic use paired with higher standards of hygiene. You're supposed to pick up your initial load of gut flora from your mother then the environment should really do the rest.
We (rightly) keep things cleaner now, but maybe too clean?
fennecbutt · 10h ago
A friend of mine works in this space. This research probably won't be younger than Ozempic patent expiry anyway.
But a natural alternative is cool. Although is it really natural? I suppose it depends on your definition.
foxyv · 13h ago
"In mice"
monster_truck · 12h ago
I wish there was an "in mice" rule here, it's far too common. It should always be in the title
We (rightly) keep things cleaner now, but maybe too clean?
But a natural alternative is cool. Although is it really natural? I suppose it depends on your definition.