Depression Reduces Capacity to Learn to Actively Avoid Aversive Events

17 PaulHoule 1 9/17/2025, 5:20:36 PM eneuro.org ↗

Comments (1)

OgsyedIE · 3m ago
This is exactly what you'd expect if the hypothesis that depression is an evolved adaptation for surviving no-win scenarios that can only be waited out holds.

In a scenario where a disaster has negatively affected the primary productivity of the local food web (e.g. volcano, forest fire, bolide, plague or tsunami), the groups of social species that exist in an environment are likely to engage in internal strife until the food web productivity the group subsists on has returned to normality. Phenotypes which reduce activity across the board without making any changes to their distribution of activities, just hoping for things to get better on their own, are likely the phenotypes that are most successful at surviving to reproduce within conditions of intragroup strife when these infrequent disasters occur.

If this line of reasoning bears out to correctly describe the actual selection pressures that have led to the genes for depression evolving, it follows that what we call major depressive disorder is in fact the genome seeing and carrying out false positives for needing the famine-survival strategy.

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Incidentally, I first came across the theory I'm repeating here on Steven Byrne's neuroscience blog, if you want an avenue for finding sources.