Ask HN: Do you think LLMs will rapidly accelerate "hard" fields? Why / why not

1 jb2403 1 8/21/2025, 9:28:15 PM

Comments (1)

PaulHoule · 1h ago
Mostly no. In physics the problem is not that we can’t make up theories, it’s that we need a 1000x or more bigger particle accelerator to settle them. In space travel I don’t see AI making some radical new engine that makes it easy to go to the moon or mars.

Biotechnology could be a counterexample, if

https://alphafold.ebi.ac.uk/

keeps making progress that could be radical but it seems to be pattern matching proteins that occur in nature and won’t unlock access to a huge space of possible proteins that don’t occur in nature. Could it help in drug discovery, yeah, but it is not a god, you will still have to do clinical trials. I think the big problem in space travel is “How can a small number of Mars colonist make 100% of what they need to sustain themselves?” and that’s a huge systems engineering problem which that advanced biotech could take a big chunk out of —- maybe AI combining the LLM ideas with systematic search could take a chunk out of it

https://en.wikipedia.org/wiki/AlphaZero

but you need to solve 100% and there will be a huge amount of “blue collar” work to manifest it. So maybe AI doubles the speed you can get things done, maybe it speeds up things 10%.