What are memories made of? A survey of neuroscientists

"Despite the last decade’s development of optogenetic methods for artificially manipulating engrams, and subsequent claims that there is a consensus that memories are stored in ensembles of synaptic connections, it remains unclear to what degree there truly is unanimity within the neuroscientific community about the neurophysiological basis of long-term memory. We surveyed 312 neuroscientists, comprising one cohort of experts on engram research and another of general neuroscientists, to assess this community’s views on how memories are stored. While 70.5% of participants agreed that long-term memories are primarily maintained by neuronal connectivity patterns and synaptic strengths, there was no clear consensus on which specific neurophysiological features or scales are critical for memory storage. Despite this, the median probability estimate that any long-term memories could potentially be extracted from a static snapshot of brain structure was around 40%, which was also the estimate for whether a successful whole brain emulation could theoretically be created from the structure of a preserved brain. When predicting the future feasibility of whole brain emulation, the median participant estimated this would be achieved for C. elegans around 2045, mice around 2065, and humans around 2125. Notably, neither research background nor expertise level significantly influenced views on whether memories could be extracted from brain structure alone. Our findings suggest that while most neuroscientists believe memories are stored in structural features of the brain, fundamental questions about the precise physical basis of memory storage remain unresolved. These findings have important implications for both theoretical neuroscience and the development of technologies aimed at preserving or extracting memory-related information."

tl;dr: neuroscientists think there's a 40% current brain preservation techniques work well enough (under ideal circumstances) to preserve someone's brain in a way that's potentially compatible with uploading them