A glimpse inside the world of drug repurposing (2024)

Comments (1)

akoboldfrying · 29m ago

An industry insider's take on the success of Karuna Therapeutics, a biotech company acquired for $14B on the strength of their schizophrenia drug KarXT. What struck me was the combination of how simple and almost obvious the fundamental scientific idea was (combine a drug that is known to be effective against schizophrenia but had unpleasant side effects, with a drug that decreases those side effects), and the enormous 16-year slog required to get it over the line. Some insights on (biotech) VCs too.

Clothes Swap and Virtual Try-On (aiactionfigure.cc)

Caltrain official lived in secret apartment built illegally inside train station (sfstandard.com)

LibreOffice drops support for Windows 7, 8 and 8.1 in 25.8 Beta 1 (neowin.net)

APL Style: Patterns/Anti-Patterns (2017) (sway.cloud.microsoft)

SQLite Date and Time Functions (www2.sqlite.org)

In San Francisco, Waymo Has Now Bested Lyft. Uber Is Next (underscoresf.com)

Why I Joined Doge (podcasts.apple.com)

CRMArena-Pro: LLM Agents Assessed Across Diverse Business Scenarios (arxiv.org)

LLM Chat via SSH (github.com)

A glimpse inside the world of drug repurposing (2024) (trevorklee.substack.com)

SHOW HN: Turn Docs into Custom GPT (Free,NoCode)- Uses Supabase DB and ChatGPT (knowbase-chrisbuilds.replit.app)

Generate Liquid Glass UI Effects – Inspired by iOS 26 (liquid-glass.pro)

OxCaml is Jane Street's branch of OCaml (bsky.app)

299,792,458: The Number That Connects Pyramids to Light Speed (pyramids.bridgerb.com)

'Nothing will be the same again': Portugal's Chega may be spot on (theguardian.com)

The State of React and the Community in 2025 (blog.isquaredsoftware.com)

Memoir: Lifelong Model Editing with Minimal Overwrite Informed Retention for LLM (arxiv.org)

DIYRE: DIY Audio Projects (diyrecordingequipment.com)

Can you hear a 51% duty cycle (youtube.com)

Institutional Books by Institutional Data Initiative (institutionaldatainitiative.org)

Green Tea Garbage Collector (github.com)

What happened to Air India 171 (youtube.com)

For All That Is Good About Humankind, Ban Smartphones (jacobin.com)

Elicitation (june.kim)

Tailscale Founder Talks Future IPO as Revenue Surges on AI Adoption (bloomberg.com)

On the Usability of Editable Software (flak.tedunangst.com)

Plotform – Product Hunt but for your book launches (plotform.cc)

$100 Hamburger (en.wikipedia.org)

Pip's Quake (blitter.net)

Exploring the Dangers of AI in Mental Health Care (hai.stanford.edu)

Review: 'Print the Legend' gives form to 3-D printer companies' history (2014) (latimes.com)

SIMD-friendly algorithms for substring searching (0x80.pl)

After 18 Years of Infertility, an AI Tool Let a Couple Conceive (today.com)

Building a WordPress MCP server for Claude (val.demar.in)

Chebfun: Open-source package for computing with functions to 15-digit accuracy (chebfun.org)

Let's Play some Glider 4.0 with John Calhoun [video] (youtube.com)

Show HN: I created an AI form builder and it's free (minform.io)

Experimental Spacetime Distortion: Generating Gravitational Waves in the Lab (ej-eng.org)

UK unis to cough up to £10M on Java to keep Oracle off their backs (theregister.com)

The secret fast track for animal drugs (worksinprogress.co)

Comment on the Illusion of Thinking (arxiv.org)

Premium accounts to fund the matrix.org homeserver (matrix.org)

Anne Wojcicki to buy back 23andMe and its data for $305M (cnbc.com)

DHS is using CBP Home Mobile App to incentivize the voluntary self-deportation (dhs.gov)

Filedb: Disk Based Key-Value Store Inspired by Bitcask (github.com)

Venusian pancake dome likely formed due to elastic lithosphere and dense lava (phys.org)

Culinary Ocean that Separates the US and Europe: innards (1993) (nytimes.com)

Why do French men pee on the street [video] (bbc.com)

Baking the Y Combinator from scratch (again) (the-nerve-blog.ghost.io)

ArkFlow and Python: Easy Real-Time AI (arkflow-rs.com)

A glimpse inside the world of drug repurposing (2024)

Comments (1)