SSRIs induce cardiac toxicity through dysfunction of mitochondria and sarcomeres

14 XzetaU8 7 5/17/2025, 12:55:18 PM nature.com ↗

Comments (7)

devwastaken · 2h ago
SSRI’s would be illegal if they werent so profitable. modern society creates the environment where humans are removed from nature.
valec · 6h ago
in fetuses.
Mo3 · 5h ago
I had to get off my SSRI because I'm apparently prone to prolonged QT interval and the SSRI could cause sudden cardiac arrest. (I am not a fetus)
washadjeffmad · 4h ago
Before the rest of them arrive, could you also confirm that you are not a mouse?
reify · 4h ago
Upon reading this you may well think that I am some sort of conspiracy theorist.

I am in fact a retired Psychotherapist, in professional practice for over 25 years.

I have seen my fair share of damage to my patients and clients caused by SSRI's.

One of the most dangerous prescribed drugs on the planet.

Its a big con.

chemical imbalance is a myth.

There is no such thing as chemical imbalance, this myth was manufactured by drug companies in the late 1980's to sell SSRI's to the unsuspecting public.

SSRI's create a paradoxical reaction.

meaning that the drug creates the depressive sympsoms experienced by the patient.

Some studies have been published that show that these antidepressants may deteriorate the state of the depression (make it worse) and even cause suicidal ideation or action.

2018 paper https://fse.studenttheses.ub.rug.nl/21028/1/Thesis-Neurobiol...

paradoxical reaction, a guide https://en.wikipedia.org/wiki/Paradoxical_reaction

It has taken over 30 years for drug companies to accept that SSRI's cause sexual disfunction and has finally been included in the DSM5 as PSSD, post ssri sexual disfunction.

In some unpublished phase 1 trials of the drug, more than 50% of healthy volunteers developed severe sexual problems. but they kept it quiet.

Highlighted in the Guardian just last year.

https://www.theguardian.com/society/2024/mar/02/ssri-antidep...

dttze · 3h ago
Psychotherapy is the con imo. Ssris can be life savers for those with anxiety based disorders.
AStonesThrow · 3h ago
When I was 19, my parents sent me to see a therapist. This therapist's office was in the Children's Hospital, and it was already humiliating to walk into that place as a grown man and there is a waiting room with toys and building blocks for me to play with.

Anyway, the therapist gave me a few "pep-talk sessions" which did not seem oriented at all to helping me get better, or discern the root causes of my depression. The therapist proceeded to help me claim disability at work and get back into college. He also referred me to his next-door neighbor, the psychiatrist.

So I go home with my first SSRI prescription and start taking it. My mother soon exclaimed how much better I was acting. I was smiling and full of energy.

And it turns out that whether or not we are ingesting fluoride orally, people do act and feel better when they are seeing a therapist and getting attention. For a time there, I actually felt like people cared about my well-being and there were things being done about it.

Upon my diagnoses, the nurses would often regale me with stories about how the noblest politicians and artists were afflicted with the same things I was. This was cold comfort. They all insisted it was a chemical imbalance, and their own cocktail of chemicals was bound to offset this crazy wrong-headed chemistry that had gotten mixed up in my head (nevermind that most serotonin has nothing to do with the brain, and is mostly in your digestive system?)

Now there were many dark things I didn't know about the fluoride pills they had prescribed me. I suffered several disastrous interactions with alcohol before they told me it's not a good idea to drink. I had those "brain zap" withdrawal symptoms when I hadn't taken enough.

Thankfully, I did not experience the suicidal or homicidal tendencies which can come with taking SSRIs. Yes, homicide is a common reaction to being drugged. Before SSRIs, Charles Whitman loved his Dexedrine, and packed a goodly supply as he scaled the tower in Texas. The Columbine Kids, very intelligent boys, had all been referred to BH care and were all being medicated with SSRIs and other drugs at the time of their untimely deaths and egregious actions.