Ask HN: What are you working on? (May 2025)

169 points by david927 8h ago 485 comments

What's been your biggest technical bottleneck as a small startup lately?

5 points by devralcomp 4h ago 0 comments

Ask HN: Selling software to company I work for as an employee

58 points by apohak 4d ago 54 comments

Ask HN: Go deep into AI/LLMs or just use them as tools?

176 points by pella_may 1d ago 132 comments

Ask HN: Career Change Confusion

11 points by tdnka 12h ago 10 comments

Ask HN: Can you give tips on writing a README for project?

6 points by vseplet 1d ago 7 comments

Ask HN: How do you promote your personal projects with a limited budget?

129 points by javafactory 4d ago 89 comments

Ask HN: What HN posts inspired or changed your perspective the most?

45 points by hungle9 3d ago 23 comments

Ask HN: What's your favorite architect/editor pair with Aider?

14 points by 34679 1d ago 1 comments

ESP32 MCP Server

10 points by horw 2d ago 9 comments

Ask HN: Do you have a side project you're getting tired of?

29 points by gdulli 3d ago 23 comments

Ask HN: How to Make Friendster Great?

94 points by ca98am79 4d ago 137 comments

It's 2025, AI is everywhere, why can't something summarize podcasts for me?

5 points by bilsbie 15h ago 1 comments

Ask HN: Senior SaaS developer wanting to pivot

4 points by heyheyhey 1d ago 9 comments

Ask HN: What projects do you donate to?

5 points by xeonmc 2d ago 7 comments

Ask HN: AI Reading List

12 points by TheAlchemist 2d ago 4 comments

Ask HN: How do you keep on top of all of the AI tools and new changes?

7 points by limonkufu 4d ago 12 comments

We sold our first AI agent to a legacy industry–now we're stuck. Help us Advice?

12 points by goldmanX 3d ago 14 comments

I spent 15 years developing a tool to make sense of software version numbers

31 points by a1tern 5d ago 5 comments

Ask HN: Places in the UK / Europe Related to computers

11 points by sailorganymede 3d ago 16 comments

Ask HN: Pros and cons of offering a self-hosted version of your SaaS?

16 points by DavyCreddy 4d ago 6 comments

Modern Python Boilerplate – good package basic structure

11 points by lambda-science 4d ago 3 comments

Ask HN: Where to find UX design resources?

17 points by bindd 5d ago 7 comments

Ask HN: Engineering Statics and Dynamics book recommendation

10 points by areoform 4d ago 2 comments

Ask HN: Fakespot is shutting down July 1. Alternatives?

3 points by cjbarber 2d ago 1 comments

What If Every Picture You've Ever Seen Already Exists?

20 points by cin4ed 5d ago 28 comments

Tell HN: The Hetzner Experience - Invisible Outages

39 points by AmazingTurtle 5d ago 12 comments

Ask HN: Don't You Mind That LLMs Are Mostly Proprietary?

18 points by dakiol 6d ago 19 comments

AskHN: Best, simplest platform to run a Technical Interview on?

4 points by marche101 3d ago 4 comments

Ask HN: How are you using LLMs for research on a library of journal articles?

6 points by jopizio 4d ago 0 comments

Ask HN: Agent / workflow frameworks or roll your own?

4 points by dennisy 3d ago 4 comments

Ask HN: What makes a programming language great for code generation?

3 points by keithasaurus 3d ago 3 comments

Ask HN: Does the languages we speak affect the way we think?

7 points by Genius_um 5d ago 21 comments

Inhibiting 15-PGDH blocks BBB deterioration and protects mice from Alzheimer's

2 pera 1 5/25/2025, 3:42:34 PM pnas.org ↗

Comments (1)

pera · 12h ago

Original title: Inhibiting 15-PGDH blocks blood–brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury